Ultimate Guide to Poria Cocos: Health Benefits & Uses

Long trusted in Traditional Chinese Medicine, Poria Cocos is a unique underground fungus used for over two millennia to support calm, digestion, and fluid balance. Though mild in taste, it was prized for its gentle yet lasting effects on resilience and well-being.

Today, modern research is beginning to uncover what ancient practitioners long suspected—that Poria contains a variety of bioactive compounds with wide-reaching benefits for immunity, gut health, and beyond.

In this guide, we’ll explore the evolving science behind the health potential of Poria Cocos, the various reported benefits and how to choose the right Poria Cocos supplements to support your wellness journey.

Index

1. What are Functional Mushrooms?
2. What Is Poria Cocos?
3. Historical Applications of Poria Cocos
4. The Science Behind The Benefits Of Poria Cocos
5. Health Benefits of Poria Cocos
6. How To Buy A Good Quality Poria Cocos Supplement?
7. Dose, Safety, Side Effects
8. How To Take Poria Cocos Mushrooms For Health Support
9. Frequently Asked Questions
10. Resources

What are Functional Mushrooms?

Referred to as 'functional mushrooms', these edible fungi boast a diverse range of bioactive compounds. Each type of functional mushroom possesses a unique bioactive profile, contributing to its ability to support specific bodily systems. Poria Cocos, in particular, stands out for its kidney support, among other health benefits.

If you're familiar with functional mushrooms, you've likely encountered the term 'beta-glucans' or 'beta-D-glucans.' These polysaccharides play a crucial role in the immune-modulating effects of mushrooms. A more detailed exploration of Beta-Glucans will be provided in a dedicated section.

What Is Poria Cocos?

Poria Cocos is a popular medicinal and edible mushroom that is widely utilized in China and other East Asian nations for its diverse healing properties [1]. 

Poria Cocos is scientifically known as Wolfiporia cocos (F.A. Wolf) Ryvarden & Gilb, however it has been scientifically referred to by many other names such as Macrohyporia cocos (Schwein.) I. Johans. & Ryvarden, Pachyma cocos (Schwein.) Fr., Poria cocos F.A. Wolf, Poria cocos (Schw.) Wolf, Wolfiporia extensa and Sclerotium cocos Schwein [1,2]. Poria cocos is called “Fuling” in China and has also been referred to as “Tuckahoe” in North America, and “Hoelen” in Japan [3,4].

Poria cocos mushrooms grow underground on the roots of pine trees and are primarily found in East and Southeast Asia, thriving in subtropical, humid environments [1]. It is especially prevalent in countries like China, Vietnam, and Thailand [1].

Unlike most mushrooms, Poria cocos does not develop a typical mycelium (root-like) network and fruiting body. Instead, it forms dense, hardened masses of fungal mycelium called sclerotia (singular: sclerotium) [3]. These sclerotia are rich in bioactive compounds believed to contribute to the numerous health benefits attributed to Poria cocos [3].

Historical Applications of Poria Cocos

Poria Cocos has been used as part of traditional Chinese medicine for over two millennia [5]. 

Poria Cocos was documented in the ancient text Shen Nong's Materia Medica, dating back to approximately 102–200 AD, and is currently recognized in the official Chinese Pharmacopoeia [6]. As noted in the Chinese Pharmacopoeia, Poria cocos offers protective benefits for the kidneys, supports spleen function, and has calming effects on the nervous system. It is frequently used to address conditions such as fluid retention, poor appetite, palpitations, digestive issues like diarrhea, as well as anxiety and sleep disturbances [3].

According to the 2015 edition of the Chinese Pharmacopoeia, preparations containing Poria cocos made up nearly 15% of all traditional Chinese medicine formulations [1].

Due to the reported benefits of Poria Cocos, a product called “Poria cocos polysaccharide oral solution” was introduced in the 1970s as an over-the-counter health supplement [5]. Later, in 2015, the Chinese Food and Drug Administration approved a formulation named “Polysaccharidum of Poria cocos oral solution” as a pharmaceutical drug for the treatment of various cancers, hepatitis, and other conditions—both on its own and alongside chemotherapy or radiation therapy [5].

Poria cocos has held a prominent place in traditional Chinese medicine for centuries and continues to be valued today for its wide range of therapeutic benefits and clinical applications.

The Science Behind The Benefits Of Poria Cocos

Researchers have uncovered a fascinating array of natural compounds in Poria cocos. These compounds include immune-supporting polysaccharides, inflammation-balancing triterpenoids, cell-protective sterols, and a range of minerals and nutrients. While some of these compounds require alcohol or chemical solvents for extraction, many—including key immune-active polysaccharides—can be drawn out using hot water, the traditional preparation method still used today.

Polysaccharides

Poria cocos offers a wide variety of complex polysaccharides, long-chain sugars with therapeutic potential. These include water-soluble types like (1→6)-α-galactan and (1→3)-β-mannoglucan, as well as other branched glucans composed of glucose, galactose, mannose, and fucose [4,43].

Among other benefits, many of these polysaccharides are linked to:

• Immune system support [13-17] 
• Anti-inflammatory effects [17-20]
• Gut health and microbiome balance [19,20,27,30,35-38]

Some specialized types—like the FMGP (fucose-containing mannoglucan polysaccharide), have even shown the ability to block the spread of cancer cells by interfering with key signaling pathways in the body [44].

Beta-Glucans

One of the most valuable and widely studied compounds in Poria cocos is beta-glucan—a type of polysaccharide known for its ability to support and regulate the immune system.

Beta-glucans work by interacting with immune cells like macrophages, dendritic cells, and natural killer cells. This "immune awakening" effect helps the body respond more effectively to stress, pathogens, and inflammation. In scientific terms, beta-glucans are classified as biological response modifiers—meaning they help "modulate" immune activity, enhancing or calming it as needed [45,46].

The primary form found in Poria cocos is β-(1→3)-D-glucan, often with β-(1→6) branches [47,48]. These specific structures are known for their immune-balancing and anticancer potential [49]. Even better, this form of beta-glucan is water-extractable, meaning it can be naturally pulled from the fungus using traditional hot water methods [4].

Triterpenoids

Triterpenoids are another major class of compounds found in Poria cocos. While not water-soluble, these compounds are responsible for many of the fungus’s more targeted effects, such as:

• Helping to manage inflammation 
• Supporting liver and kidney function
• Regulating blood sugar and lipid levels

Notable triterpenoids like pachymic acid and poricoic acid A have been studied for their ability to slow tumor growth [50], protect the kidneys [51], and modulate immune responses [52]. Although most triterpenoids require alcohol or organic solvents for full extraction, trace amounts may be present in hot water extracts prepared through prolonged decoction.

Sterols

Sterols found in Poria cocos—such as ergosterol and β-sitosterol—are structurally similar to cholesterol and may help:

• Support cell membrane integrity 
• Promote healthy lipid metabolism
• Reduce oxidative stress

While sterols are generally fat-soluble and less extractable through water, their presence complements the overall spectrum of compounds in the fungus [39,53].

Other Nutrients and Trace Elements

In addition to its major compounds, Poria cocos also contains:

• Organic acids like protocatechuic and palmitic acid  [39]
• Minerals such as iron, zinc, manganese, and selenium, essential for immune and metabolic function [39]
• Natural proteins and volatile oils, some of which may play a role in immunity and digestion
  

Health Benefits of Poria Cocos

Health Benefits at a Glance:

1. Poria Cocos May Support Kidney Health
2. Poria Cocos May Strengthen Immune Function
3. Poria Cocos May Help Combat Inflammation
4. Poria Cocos May Support Antioxidant Activity
5. Poria Cocos May Provide Cognitive Function & Mood Support
6. Poria Cocos May Provide Insomnia Relief
7. Poria Cocos May Support Blood Sugar, Weight & Metabolic Balance
8. Poria Cocos May Protect Heart Health
9. Poria Cocos May Support Liver Health
10. Poria Cocos May Provide Skin Protection
11. Poria Cocos May Support Anti-Tumour Effects
12. Poria Cocos May Support Gut Health

Poria Cocos May Support Kidney Health

Traditional medicine has long used Poria Cocos for its diuretic and kidney-supportive properties. Today, modern research is beginning to uncover how its active compounds—particularly its water-soluble polysaccharides—may help protect and support kidney function. Studies in both animal models and cell cultures suggest that Poria Cocos may offer benefits ranging from reducing inflammation and oxidative stress to improving metabolic balance, fluid regulation, and even stem cell activity related to kidney repair. Below is a breakdown of the emerging science behind its potential kidney-protective effects.

Helps Maintain Kidney Function in Chronic Disease

Research on Poria Cocos epidermis, the outer layer of the medicinal mushroom, suggests it may help slow the progression of chronic kidney disease (CKD). In one study, Zhao et al. [7] used advanced metabolomic techniques to examine how Poria Cocos affected rats with early kidney damage. They found that treatment with the epidermis extract helped normalize several key metabolites that become imbalanced during CKD.

These included markers involved in fatty acid metabolism, phospholipid metabolism, and waste-processing compounds like indoxyl sulfate and hippuric acid [7]. When left unchecked, these compounds can worsen kidney function. The normalization of these markers in treated rats points to a possible protective role for Poria Cocos in early-stage kidney dysfunction.

May Protect Kidneys from Inflammation and Oxidative Stress

Another study looked at the antioxidant and kidney-protective effects of a Poria extract (PE) in both cell and animal models. Wagmaister et al. exposed kidney cells to oxidative stress and found that PE helped protect the cells and maintain their viability [8]. In rats given adenine—a chemical that induces kidney damage—those treated with the extract had significantly improved kidney function and lower levels of kidney injury markers. The antioxidant effects of PE appeared to reduce oxidative stress, which is a major contributor to long-term kidney damage.

Modulates Key Kidney-Related Metabolic Pathways

In further work by Zhao et al, researchers used a urine metabolomics approach to understand how Poria Cocos epidermis might protect against kidney injury [9]. Rats with adenine-induced CKD showed a distinct pattern of disrupted metabolism, especially in amino acid and adenine-related pathways. After treatment with Poria Cocos epidermis, several of these disrupted biomarkers returned to normal levels [9]. The findings suggest that the extract may help restore the body’s natural metabolic balance during chronic kidney injury.

Improves Fluid Balance and Reduces Swelling

Traditional Chinese medicine has long used Poria Cocos to address edema and fluid imbalance. This use is supported by modern studies. Lee et al.tested the effects of Poria Cocos in rats with nephrotic syndrome—a condition that causes severe swelling and protein loss through urine [10]. They found that animals treated with a dried sclerotia extract had significantly less fluid buildup (ascites) and protein leakage. The extract also influenced proteins like AQP2 and ENaC, which are involved in regulating how the kidneys manage water and sodium. By reducing the expression of these channels, Poria Cocos helped prevent fluid overload.

Supports Stem Cell Activity for Kidney Repair

One of the more advanced areas of research explores how Poria Cocos polysaccharides may help the kidneys regenerate. A study by Fu et al. found that these polysaccharides stimulated the proliferation and differentiation of bone marrow-derived mesenchymal stem cells (BM-MSCs), which are being explored for their potential in kidney repair [11]. Treated stem cells not only multiplied more effectively, but also produced fewer pro-inflammatory molecules. This suggests that Poria Cocos may support the body’s ability to naturally repair damaged kidney tissue by promoting anti-inflammatory stem cell behavior.

Multi-Pathway Activity in Inflammatory Kidney Disease

In a recent network pharmacology analysis, Liu et al. examined how the combination of Poria Cocos and Licorice might treat Henoch–Schönlein purpura nephritis (HSPN), an inflammatory kidney disease [12]. The study identified over 100 active ingredients and their cellular targets, and matched them against known disease genes. Key signaling pathways, including TNF, HIF-1, and IL-17, were implicated—suggesting that Poria Cocos may influence immune system responses and inflammation in the kidneys. While some of the mapped compounds may not be present in hot water extracts, the study still offers valuable insights into the multi-target potential of Poria Cocos in renal health.

Together, these studies provide converging evidence that Poria Cocos—especially its water-soluble polysaccharides—may help support kidney health by reducing inflammation, promoting tissue recovery, supporting metabolic regulation, and improving fluid balance [7-12]. While most research to date is preclinical, the consistency of the findings across different models makes this a promising area for further investigation.

Poria Cocos May Strengthen Immune Function

Modern studies are beginning to confirm what traditional medicine has long suggested—Poria Cocos polysaccharides (PCPs) may help regulate and enhance the immune system in important ways. These benefits are especially relevant in the context of both general immune health and potential use in vaccines or disease prevention.

One of the key ways PCPs support immunity is by activating macrophages and dendritic cells, which are front-line defenders in the immune system. In research by Gu et al., a specific water-soluble polysaccharide from Poria Cocos was shown to stimulate these cells and enhance the response to a model vaccine antigen [13]. Not only did PCP boost antibody production, but it also triggered a balanced Th1/Th2 immune response, which is important for both short-term and long-term immune protection. Most notably, PCP promoted the activation of cytotoxic T cells, the type of immune cells that help eliminate virus-infected or cancerous cells—something that standard aluminum-based vaccine adjuvants typically cannot do as effectively [13].

This effect is further supported by Tian et al., who found that PCP increased levels of several important immune signaling molecules, including interleukin-2 (IL-2), IL-6, IL-17A, tumor necrosis factor (TNF), and interferon-gamma (IFN-γ) [14]. These cytokines play critical roles in immune coordination and defense. Interestingly, this immune activation relied on a pathway known as TLR4/TRAF6/NF-κB. When TLR4 was blocked or absent in mice, PCP had little effect—strongly suggesting that this receptor is key to its immune-enhancing abilities [14].

Additional research by Zhang et al. explored how two other polysaccharides isolated from Poria Cocos—PCWPW and PCWPS—affect macrophages [15]. Their study found that both compounds increased the production of TNF-α and activated immune-related genes. These effects were shown to depend on mannose receptors on the surface of immune cells and involved the NF-κB/MAPK signaling pathway, which plays a central role in immune regulation and inflammation [15].

For even greater immune support, Xu et al. developed a novel nanoparticle-based delivery system called PCP-hMnOx, where the Poria Cocos polysaccharide was loaded onto biodegradable honeycomb manganese oxide particles [16]. This system enhanced antigen uptake by immune cells, boosted both antibody and T-cell responses, and triggered higher levels of IFN-γ—a key antiviral cytokine.

Compared to traditional alum adjuvants, the PCP-hMnOx system produced a more complete immune response, with strong CD4+ and CD8+ activation and formation of germinal centers in lymph nodes, where long-term immune memory is formed [16].

Beyond vaccine support, Poria Cocos may help protect the immune system during illness. In a study by Wu et al., mice facing fecal-induced peritonitis—a model for severe abdominal infection—showed reduced inflammation and oxidative stress when pre-treated with PCP [17]. The extract lowered inflammatory markers like TNF-α, IL-6, and IL-1β, reduced immune cell death in the spleen and thymus, and helped normalize levels of protective antioxidants such as glutathione (GSH) and superoxide dismutase (SOD). Importantly, PCP also moderated regulatory T cells (Tregs), which, when overactive, can suppress immune function [17].

Together, these studies suggest that Poria Cocos polysaccharides may offer broad immune benefits—from enhancing pathogen-fighting responses to reducing damaging inflammation and improving immune balance [13-17]. Whether used alone or in combination with other therapies, these natural compounds show promising potential as immune modulators for both wellness and clinical applications.

Poria Cocos May Help Combat Inflammation

Chronic inflammation is a driver behind many modern health conditions, from infections to liver disease and reproductive disorders. Recent scientific studies suggest that Poria Cocos polysaccharides (PCPs)—naturally occurring sugar-based compounds found in the mushroom—may help reduce inflammation by targeting several biological pathways involved in the body’s immune and inflammatory responses.

In one study, Wu et al. investigated how PCPs affected mice suffering from fecal-induced peritonitis, a severe type of inflammation caused by bacterial infection in the abdomen [17]. These mice typically develop very high levels of inflammatory molecules like TNF-α, IL-6, and IL-1β, as well as markers of oxidative stress such as MDA and MPO. PCP treatment significantly lowered these inflammatory and oxidative markers while boosting the body’s own antioxidant defenses, including superoxide dismutase (SOD) and glutathione (GSH). Additionally, PCP reduced tissue damage in key immune organs and helped regulate Treg cells, which are involved in immune balance [17]. These effects point to a broad anti-inflammatory, antioxidant, and tissue-protective role for PCPs.

A separate study by Huang et al. focused on bovine endometritis, a reproductive disease marked by bacterial inflammation in the uterus [18]. Using both cell cultures and a rat model of the disease, researchers found that PCP significantly reduced cell damage and inflammation while improving antioxidant activity in uterine tissue. Treated rats showed lower levels of inflammatory markers in their blood and a visible reduction in swelling and tissue damage. The study concluded that PCP helped inhibit apoptosis (cell death) and regulate gene pathways associated with inflammation, offering potential therapeutic benefits even in complex inflammatory conditions [18].

Liver inflammation is another area where Poria Cocos shows promise. In a study on alcoholic liver disease (ALD), Jiang et al. found that a specific polysaccharide extract called PCP-1C reduced inflammation in the liver by blocking the TLR4/NF-κB signaling pathway—a well-known trigger for immune overactivation [19]. PCP-1C also helped protect liver cells from oxidative damage and reduced intestinal leakiness, which normally allows harmful substances to enter the bloodstream and worsen liver inflammation [19]. This dual action—protecting both liver and gut—suggests a powerful systemic anti-inflammatory potential.

Even in the context of stress-related inflammation, Poria Cocos may be beneficial. Zhang et al. examined rats with chronic sleep deprivation, a condition known to raise stress hormones and trigger inflammation in both the brain and gut.

Treatment with Poria Cocos water-soluble polysaccharides (PCWP) helped normalize levels of inflammatory cytokines and inhibited the TNF-α/NF-κB pathway, while also improving gut microbiota composition [20]. This study shows that Poria Cocos may reduce inflammation not only in isolated organs but across the gut–brain axis, which plays a key role in overall well-being.

Together, these findings support the idea that Poria Cocos polysaccharides may help combat inflammation through multiple mechanisms—lowering inflammatory cytokines, reducing oxidative stress, protecting tissues, and regulating immune responses [17-20]. Whether inflammation is triggered by infection, liver injury, reproductive disorders, or stress, PCP appears to offer a safe and natural approach to restoring balance and protecting long-term health.

Poria Cocos May Support Antioxidant Activity

Oxidative stress is a condition where harmful molecules called free radicals build up in the body faster than they can be neutralized. This imbalance contributes to inflammation, tissue damage, and the progression of many chronic diseases. Antioxidants are the body’s natural defense against this process—and according to growing research, Poria Cocos may be a valuable source of support.

Water-soluble polysaccharides extracted from Poria Cocos have been shown in multiple studies to help the body manage oxidative stress in a variety of ways. In one foundational study, Wang et al. compared four different extraction methods for isolating these polysaccharides, including hot water extraction—a traditional and widely used method [21]. The hot water-extracted polysaccharides (referred to as PCP-H) were found to contain beneficial sugars such as mannose, glucose, and galactose. In antioxidant lab tests, PCP-H showed meaningful free radical scavenging activity, the ability to neutralize harmful oxidants, and mild metal-chelating properties, which help prevent metals from catalyzing oxidative damage.

Although not the most potent extract in the study, PCP-H still demonstrated consistent antioxidant effects, supporting its relevance in formulations made using traditional hot water methods [21].

A different study by Wu et al.  further confirmed the antioxidant benefits of Poria Cocos polysaccharides in a live animal model [17]. Mice with severe inflammation and infection (known as fecal-induced peritonitis) were treated with PCP in advance.

These mice typically show high levels of oxidative stress, but PCP pre-treatment increased protective enzymes like superoxide dismutase (SOD) and glutathione (GSH) while reducing harmful markers such as malondialdehyde (MDA) and myeloperoxidase (MPO) [17]. These biochemical shifts were linked to less tissue damage, improved immune organ function, and greater resistance to infection—demonstrating how PCPs may help the body maintain balance under extreme physiological stress.

The potential neuroprotective benefits of PCP’s antioxidant action have also been studied. In a rat model of Alzheimer’s disease, Zhou et al. found that PCP administration helped reduce brain inflammation and oxidative damage in the hippocampus, a region crucial for memory [22]. Antioxidant enzymes were elevated, while damaging compounds like ROS and MDA were significantly reduced. These changes contributed to improved learning and memory, as well as healthier brain tissue. The study suggests that the antioxidant properties of PCP may play a central role in protecting brain cells from age-related decline [22].

In the area of skincare, Fang et al. investigated whether Poria Cocos extract could protect human skin cells from oxidative stress caused by hydrogen peroxide—a common model for skin aging [23]. The extract helped prevent cell death, reduced free radical accumulation, and lowered the expression of enzymes that break down collagen. It also boosted antioxidant proteins and increased TGF-β1, a factor important for maintaining skin structure. These findings point to the potential use of Poria Cocos as a natural ingredient in skincare aimed at reducing oxidative skin damage [23].

Finally, oxidative stress doesn’t just affect the skin and brain—it can also damage organs like the kidneys. In a study by Wagmaister et al., researchers examined the protective effects of Poria extract in rats with kidney damage induced by adenine [8]. The extract helped maintain kidney structure and reduced oxidative stress by about 27%, even when the kidneys were under chemical assault. Lab-grown kidney cells exposed to hydrogen peroxide were also protected by the extract, showing that Poria Cocos may help safeguard against damage at both the cellular and organ level [8].

Taken together, these studies present strong early evidence that Poria Cocos polysaccharides may offer meaningful antioxidant support. They appear to work by boosting the body’s natural enzymes, reducing the buildup of harmful oxidative molecules, and protecting vital tissues from damage [8,17,21-23]. This positions Poria Cocos as a promising natural option for those seeking to support cellular health and resilience in the face of environmental, metabolic, or age-related oxidative stress.

Poria Cocos May Provide Cognitive Function & Mood Support

Modern research suggests that Poria Cocos polysaccharides (PCPs) may help support both brain function and emotional well-being. These natural compounds appear to act through multiple mechanisms—protecting brain cells, reducing harmful inflammation, and even influencing the body’s neurotransmitter systems involved in mood and memory.

In a 2021 study, Zhou et al. investigated how PCPs affected memory and brain health in rats modeled to mimic Alzheimer’s disease [22]. The animals were exposed to chemicals that damage the brain, leading to memory loss and cellular degeneration in the hippocampus—a key region for learning. However, daily PCP treatment for 30 days significantly reduced brain cell damage, preserved hippocampal structure, and improved performance on memory tests. The researchers also found that PCP increased the activity of antioxidant enzymes and reduced inflammatory markers in the brain [22]. These protective effects were linked to the inhibition of the MAPK/NF-κB signaling pathway, which plays a major role in neuroinflammation. Together, these results suggest that PCP may help preserve cognitive function by protecting neurons from oxidative stress and inflammation.

Research by Zhang et al. explored the mood-related effects of Poria Cocos polysaccharides in a mouse model of depression [24]. Two specific fractions, known as PCWPW and PCWPS, were tested using standard behavioral tests like the forced swim and tail suspension tests—models commonly used to evaluate antidepressant activity. Mice given the polysaccharides showed significantly reduced depression-like behaviors. In addition to their behavioral effects, these polysaccharides also protected cultured nerve cells from oxidative damage and showed immunomodulatory effects, suggesting they may influence both neurological and immune pathways linked to mood regulation [22].

Another important study by Zhang et al. looked at how Poria Cocos polysaccharides might help with emotional balance under stress [20]. In rats subjected to chronic sleep deprivation—a condition known to disrupt mood and brain chemistry—researchers observed classic signs of anxiety and neurotransmitter imbalance.

Treatment with Poria Cocos polysaccharides reversed many of these effects: levels of key brain chemicals like serotonin, dopamine, norepinephrine, and GABA increased, and inflammation in the brain was reduced. The treatment also improved the diversity and balance of gut bacteria, which are closely linked to mood through the gut-brain axis. These changes were again associated with suppression of the TNF-α/NF-κB pathway, reinforcing the idea that Poria Cocos helps regulate brain inflammation in stressful situations [20].

Finally, a study by Xu et al. evaluated the cognitive benefits of Poria Cocos using a well-known test of memory in mice [25]. Animals were treated with scopolamine, a compound that induces memory impairment, and then given different Poria Cocos extracts. The results showed that crude and refined polysaccharides from Poria Cocos significantly improved memory performance, as shown by quicker learning in the Morris water maze. In addition, levels of acetylcholinesterase—an enzyme that breaks down the memory-supporting neurotransmitter acetylcholine—were reduced in the brain [25]. This suggests that PCPs may also enhance cognitive performance by helping maintain healthy acetylcholine levels.

Altogether, these studies indicate that Poria Cocos polysaccharides may offer multi-pathway support for brain health—helping protect neurons, reduce inflammation, enhance memory, and balance mood-related neurotransmitters [20,22,24,25]. While more research is needed in humans, the evidence so far makes this traditional ingredient a promising natural ally in supporting cognitive clarity and emotional resilience.

Poria Cocos May Provide Insomnia Relief

Difficulty falling asleep or staying asleep is a common issue that can take a toll on both mental and physical health. Recent research suggests that Poria Cocos may offer gentle, natural support for better sleep by interacting with the brain’s calming pathways and helping to regulate the body’s internal rhythm.

A 2022 study tested the effects of Poria Cocos extract (PCET) on several rat models of sleep disturbance [26]. In normal rats and those made more alert with caffeine, PCET was shown to reduce sleep latency—meaning it helped the animals fall asleep more quickly—and increase total sleep time. In another model using ACTH (a hormone that disrupts sleep), PCET administration led to a measurable increase in non-REM sleep, which is the deep, restorative phase critical for rest and recovery.

Using EEG technology, the researchers confirmed that PCET improved overall sleep structure and depth. They also found that the benefits were likely due to activation of the GABA-A receptors, which help calm the nervous system and reduce overactivity in the brain [26]. This supports the idea that Poria Cocos may work in a similar way to some sleep aids—by enhancing the body’s natural inhibitory signals to promote relaxation and sleep readiness.

These findings are supported by earlier work from Xu et al , who evaluated the sedative and hypnotic effects of different components of Fuling (the dried sclerotium of Poria Cocos) [25]. In their study, mice were given various extracts of the mushroom, including crude and refined polysaccharides. Results showed that these polysaccharide components significantly reduced the time it took for mice to fall asleep (sleep latency) and increased the total time spent asleep when sleep was induced with pentobarbital, a barbiturate used to model sedative response [25].

The researchers concluded that the calming effects of Poria Cocos were tied to its natural “sweet” properties in Traditional Chinese Medicine terms, which are traditionally associated with tonifying the spleen and calming the mind.

Together, these studies suggest that Poria Cocos polysaccharides may help promote restful sleep by calming brain activity, shortening the time it takes to fall asleep, and increasing time spent in deep, restorative sleep stages [25,26]. While more clinical research in humans is still needed, the evidence from animal models supports its use as a gentle, plant-based option for those struggling with poor sleep quality or stress-related sleep disruption.

Poria Cocos May Support Blood Sugar, Weight & Metabolic Balance

Poria Cocos polysaccharides (PCPs) have shown promising effects in helping the body manage key aspects of metabolic health, including blood sugar regulation, fat metabolism, and weight-related inflammation.

In a 2024 study, Jiang et al. explored how PCPs influenced obesity-related outcomes in mice fed a high-fat diet [27]. The findings revealed that PCPs helped reduce inflammation in fat tissue and supported healthier fatty acid metabolism. Notably, PCP treatment led to improvements in gut microbiota diversity, with increases in beneficial bacteria such as Lachnospira and Dorea. These changes were associated with better energy balance and reduced signs of metabolic disturbance. The study also identified 35 genes linked to inflammation, lipid metabolism, and insulin signaling that were positively modulated by PCP, suggesting a wide-reaching benefit across multiple systems involved in weight regulation and metabolic function [27].

In addition to supporting weight and fat metabolism, Poria Cocos may also aid in blood sugar control. A comprehensive meta-analysis involving over 6,400 participants examined how traditional herbal formulas containing Poria Cocos affected individuals with type 2 diabetes [28]. When used alongside conventional glucose-lowering medications, these formulas significantly reduced fasting blood glucose, post-meal glucose levels, and HbA1c (a long-term marker of blood sugar control). Importantly, these benefits were achieved without an increase in adverse side effects, highlighting the potential of Poria Cocos as a well-tolerated complementary option for managing blood sugar [28].

Together, these findings suggest that Poria Cocos may provide multi-faceted support for people aiming to maintain healthier weight, improve metabolic balance, or manage blood sugar more effectively—especially when supported by good dietary and lifestyle habits.

Poria Cocos May Protect Heart Health

Heart damage caused by poor blood flow—such as during a heart attack—can lead to serious and lasting effects if not properly managed.

In a 2023 animal study, researchers investigated whether Poria Cocos polysaccharides (PCP) could protect the heart from this kind of damage, specifically in a model of myocardial ischemia-reperfusion injury (MI/RI), which mimics the heart stress that occurs when blood supply returns after a temporary blockage [29].

In this study, rats were given either a low or high dose of PCP before being subjected to a temporary blockage of a key heart artery. Compared to untreated animals, those that received PCP had smaller areas of heart tissue damage, healthier-looking heart cells under the microscope, and significantly lower levels of enzymes like LDH and CK-MB, which are typically elevated when the heart muscle is injured.

PCP also had a noticeable effect on reducing inflammation and oxidative stress in the heart. Levels of harmful molecules like IL-1β, IL-18, and malondialdehyde (MDA) were lower in the PCP-treated groups, while levels of superoxide dismutase (SOD)—an antioxidant enzyme that protects cells—were higher. This suggests that PCP helped neutralize oxidative damage, which is a key contributor to heart cell death during and after ischemic events.

Further analysis showed that PCP influenced proteins involved in regulating cell survival and inflammation, including reducing the expression of pro-apoptotic markers like Bax and cleaved caspase-3, and increasing levels of Bcl-2, a protein that helps cells resist programmed death. PCP also appeared to block the Rho-ROCK signaling pathway, which is associated with stress responses in heart cells and plays a role in promoting inflammation and fibrosis.

Taken together, these results suggest that Poria Cocos polysaccharides may help protect heart tissue, especially during times of circulatory stress, by reducing oxidative damage, limiting inflammation, and promoting better cell survival [29]. While these findings come from animal models, they point to a promising natural approach to cardiovascular support that deserves further study.

Poria Cocos May Support Liver Health

Your liver is one of the body’s most important organs—responsible for detoxifying harmful substances, processing nutrients, and supporting your immune system.

However, it's also vulnerable to damage from alcohol, medications like paracetamol (acetaminophen), poor diet, and chronic inflammation. New research suggests that Poria Cocos polysaccharides (PCPs) may help protect the liver by addressing multiple causes of liver injury at once.

One study by Jiang et al. looked at alcohol-induced liver disease, which commonly leads to inflammation, fat buildup in the liver (steatosis), and what's known as a "leaky gut," where harmful toxins from the digestive tract enter the bloodstream [19]. In mice with liver damage caused by alcohol, PCP-1C (a purified Poria Cocos polysaccharide) reduced key signs of liver stress. It lowered levels of liver-damaging enzymes, decreased fat accumulation, and blocked inflammatory pathways like TLR4/NF-κB [19]. Just as importantly, it strengthened the gut barrier, reducing the leakage of toxins into the liver that can trigger more inflammation.

Another important study by Tan et al. explored the effects of PCP on non-alcoholic steatohepatitis (NASH), a serious form of fatty liver disease not caused by alcohol [30]. In this case, mice were fed a diet that mimicked the effects of poor nutrition and metabolic stress. The group receiving Poria Cocos had less liver scarring, less oxidative damage, and better liver function overall. Interestingly, PCP also helped rebalance the gut microbiome, increasing beneficial bacteria while reducing the presence of endotoxins that worsen liver inflammation. It achieved this partly by suppressing the NF-κB/CCL3/CCR1 signaling pathway, which is known to drive chronic inflammation in liver disease [30].

Poria Cocos has also been shown to protect the liver from acetaminophen (paracetamol) overdose, which is a leading cause of sudden liver failure. In a series of studies, Wu et al. found that mice pre-treated with PCP had much lower levels of liver enzymes that indicate damage (like ALT, AST, and LDH) [31-33]. Their livers also showed fewer signs of inflammation and cell death. PCP helped increase antioxidant enzymes like SOD, reduced harmful molecules like MDA (a marker of oxidative damage), and boosted liver cell survival by increasing proteins like Bcl-2 and PCNA, while suppressing pro-death signals like Bax and caspase-3. These effects were observed in both animal livers and liver cells grown in the lab [31-33].

To understand how PCP works on a molecular level, Wu et al. also used bioinformatics and molecular docking techniques [33]. They found that pachyman, a key component of Poria Cocos, likely targets protective liver enzymes like CYP3A4 and NOS2, which are involved in detoxifying drugs and regulating inflammation. These computational predictions were supported by experiments showing improved liver structure and function in mice exposed to liver toxins [33].

In summary, modern research supports the traditional view that Poria Cocos may help maintain liver health. It appears to work through a combination of actions—reducing inflammation within the liver, protecting against oxidative stress, and preventing liver cell death. Additionally, it supports the liver’s detoxification enzymes and helps reinforce the gut barrier, which reduces the passage of harmful substances from the digestive tract into the liver.

Together, these effects suggest that Poria Cocos may be a valuable natural ally in promoting liver resilience, particularly in the context of modern lifestyle challenges such as stress, poor diet, or environmental toxin exposure [19, 30-33].

Poria Cocos May Provide Skin Protection

Oxidative stress is one of the primary drivers behind visible signs of skin aging. It occurs when harmful molecules called reactive oxygen species (ROS) build up in skin cells, often due to environmental exposures like UV radiation or pollution. This oxidative stress can trigger the breakdown of collagen, the structural protein that helps skin stay firm and elastic, leading to wrinkles, thinning, and reduced skin vitality.

In a 2021 study, Fang et al. investigated how Poria Cocos extract might help protect the skin from this kind of damage [23]. Human skin fibroblast cells were exposed to hydrogen peroxide—a compound known to generate oxidative stress and mimic aging effects in cells. These cells were then treated with a hot water extract of Poria Cocos, the same type of extraction commonly used in traditional medicine and in supplement preparations.

The results were promising. The Poria Cocos extract significantly reduced ROS accumulation, which helped prevent cell death caused by oxidative stress. It also lowered the expression of matrix metalloproteinases (MMPs)—enzymes that degrade collagen—and suppressed key inflammatory and aging-related markers in the skin cells. At the same time, it boosted levels of TGF-β1, a protein involved in collagen production, and activated the Nrf2 antioxidant pathway, a central cellular defense mechanism.

These combined effects suggest that Poria Cocos may help preserve skin structure, reduce inflammation, and counteract the cellular processes linked to aging [23]. As a result, it is being explored as a natural ingredient with potential use in skincare and cosmetic products, particularly for its role in defending the skin from environmental stress and maintaining a youthful appearance.

Poria Cocos May Support Anti-Tumour Effects

Emerging research suggests that the natural polysaccharides found in Poria Cocos may help the body defend itself against certain types of tumours, particularly by strengthening the immune system and interfering with the processes that allow cancer cells to grow and spread.

One key study by Tian et al. investigated how Poria Cocos polysaccharides (PCP) interact with immune function in both cell and animal models [14]. The results showed that PCP significantly boosted immune responses by activating important immune cells like macrophages and increasing the production of signaling molecules such as nitric oxide, TNF-α, IL-2, IL-6, IL-17A, and IFN-γ. These are all critical for mounting a defence against abnormal cell growth. The effect was linked to a specific immune signaling pathway—TLR4/TRAF6/NF-κB—which plays a major role in how the body detects and responds to threats like tumours [14].

Further supporting this, another study by Jiang and Duanmu focused specifically on human lung cancer cells (A549) [34]. Researchers found that Poria Cocos polysaccharides inhibited the proliferation, migration, and invasion of these cancer cells—key behaviours that enable tumours to grow and spread. This effect was again linked to suppression of the NF-κB signaling pathway, which is often overactive in cancer cells and contributes to inflammation and tumour progression.

PCP also lowered the expression of proteins like Ki-67 and matrix metalloproteinases (MMP-2 and MMP-9), which are commonly associated with cancer cell division and tissue invasion [34].

Taken together, these findings suggest that the polysaccharides in Poria Cocos may offer natural anti-tumour support by stimulating immune function and interfering with cancer-promoting pathways [14,34]. While more research is needed, especially in human trials, the current evidence highlights a promising role for Poria Cocos in supporting the body’s natural defences against tumour development.

Poria Cocos May Support Gut Health

A healthy gut plays a crucial role in digestion, immune strength, mood, and overall well-being. Recent research shows that polysaccharides from Poria Cocos can support gut health through multiple mechanisms: protecting the gut lining, promoting beneficial bacteria, easing inflammation, and improving metabolism.

One key way Poria Cocos supports gut integrity is by strengthening the intestinal barrier—the protective lining that filters out toxins while absorbing nutrients. In a 2023 study, Duan et al. found that Poria Cocos polysaccharides improved all layers of the gut barrier in mice [35]. They increased levels of critical sealing proteins like Occludin and ZO-1, enhanced mucosal protectants such as MUC2 and SIgA, and stimulated anti-inflammatory immune signals like IL-10 and TGF-β—together helping prevent “leaky gut” and promoting tissue repair [35].

This barrier-reinforcing effect was also seen in models of disease. For example, Jiang et al. demonstrated that in mice with alcohol-induced liver damage—where gut leakiness contributes to inflammation—Poria Cocos not only improved liver health but also helped restore gut integrity by reducing the entry of toxic bacterial byproducts like lipopolysaccharide (a large molecule found on the outer membrane of certain harmful bacteria) into the bloodstream [19].

Likewise, Xu et al. showed that in mice suffering from antibiotic-associated diarrhea, Poria Cocos polysaccharides were as effective as a commercial probiotic in improving stool quality, repairing intestinal tissue, and restoring the diversity and balance of gut bacteria [36]. Importantly, it increased levels of beneficial strains like Akkermansia and Lactobacillus, which are linked to gut lining protection and healthy metabolism.

Zou et al. extended these findings by studying chemotherapy-induced intestinal injury [37]. They found that the water-soluble fraction of Poria Cocos reversed damage to the gut wall, lowered inflammation, and shifted the gut microbiome back toward a more favorable state [37]. It also normalized levels of key gut metabolites, which are closely tied to digestion and immune function.

Tan et al. focused on a different type of stress: non-alcoholic fatty liver disease (NASH), which is often linked to gut microbial imbalance [30]. Their results showed that high-dose Poria Cocos treatment reshaped gut bacteria—boosting beneficial Faecalibaculum and lowering harmful endotoxins—while also reducing gut-driven inflammation [30]. This suggests Poria Cocos can protect the gut-liver axis in metabolic disease.

Zhang et al. explored how gut health and mood are connected [20]. In rats exposed to chronic sleep deprivation—a known disruptor of gut balance—they found that Poria Cocos not only improved microbial diversity but also helped regulate neurotransmitter levels and reduce systemic inflammation. These findings suggest a potential role in supporting the gut-brain connection [20].

The way Poria Cocos influences gut microbes may also depend on how it’s prepared. Lai et al. compared three fractions of the mushroom and found that the water-soluble polysaccharide fraction (PCX) significantly altered gut microbiota composition and increased the production of short-chain polypeptides, important signaling molecules in digestive and immune health [38]. PCX also played a role in reshaping the metabolic landscape of the gut microbiome, underlining its contribution to gut health through more than one pathway [38].

Finally, in a high-fat diet model of obesity, Jiang et al. found that Poria Cocos improved gut microbial balance by reducing inflammatory species and promoting beneficial bacteria such as Eisenbergiella and Lachnospira [27]. These changes were associated with improved fat metabolism and reduced gut-linked inflammation—further evidence that gut health is central to metabolic balance [27].

Altogether, these studies highlight that Poria Cocos supports gut health on several levels: by sealing and repairing the intestinal lining, regulating immune responses, restoring healthy microbial balance, and enhancing key metabolic functions [19,20,27,30,35-38]. Whether taken to address digestive upset, inflammation, or broader systemic issues, Poria Cocos shows significant promise as a gut-strengthening, microbiome-modulating natural ingredient.

How To Buy A Good Quality Poria Cocos Supplement?

Choosing a good quality mushroom supplement can be a daunting task, as there are many options available in the market. However, there are a few key things to consider when selecting a high-quality mushroom supplement:

Sclerotium vs. Cultured Mycelium

Quality control standards for functional mushroom products are currently lacking, highlighting the urgent need for systematic scientific verification of active compounds in these nutritional supplements. This is crucial for ensuring greater accountability regarding ingredient integrity and transparency.

With Poria Cocos, the key distinction lies in the part of the fungus being used. The sclerotium—a dense, hardened underground mass of mycelium—is the part traditionally harvested and used in Chinese medicine. It forms naturally in the soil over time and serves as a nutrient storage structure, accumulating a rich concentration of bioactive compounds.

In contrast, many modern mushroom supplements use lab-grown mycelium, which is typically cultivated quickly on grains like rice or oats. These mycelium-based products often contain more grain residue than actual fungal compounds, and are not equivalent in composition or potency to the mature sclerotium.

To ensure you are getting a high-quality Poria Cocos supplement, look for labels that specifically indicate the use of sclerotium, not just “mycelium.” Products using Poria Cocos sclerotium—rather than immature grain-grown mycelium—are more likely to reflect the composition studied in scientific research and used in traditional preparations.

Beta-Glucan Content

Beta-glucans are one of the primary compounds responsible for the various health benefits associated with mushrooms.

Many brands incorporate various starch, fillers, colourings, unnecessary additives, and other ingredients into their supplements, which offer no health benefits. Moreover, these additions suggest a low percentage of actual Poria Cocos extract in the product, resulting in a diminished concentration of beta-glucans (medicinal compounds) and, consequently, lower therapeutic potency.

To obtain the most potent and high-value functional fungi supplement, scrutinise the product label for specific beta-glucan content. To ensure the optimal quality of your Poria Cocos mushroom supplement, verify that the product specifies a beta-glucan concentration of at least 25%. This ensures you receive the full spectrum of health benefits associated with this mushroom.

Antioxi's Poria Cocos Extract boasts a beta-glucan content exceeding 30%, guaranteeing that you receive the necessary benefits.

Organically Certified

Opt for certified organic options as mushrooms tend to absorb pollutants from their surroundings. Mushrooms that are organically grown refer to mushrooms cultivated in a natural manner, devoid of herbicides, fungicides, or pesticides.

Safety Tests

Heavy metals and pesticides tests are safety tests which will indicate whether mushrooms are safe to consume.

At Antioxi, all our mushrooms are third-party tested and verified to ensure heavy metals, mycotoxins, pesticides, herbicides, microbial contaminants, ethylene oxide (ETO), and polycyclic aromatic hydrocarbons (PAHs) are all within safe limits.

Extraction Method

Understanding the ingredients in your diet is crucial, especially when it comes to functional mushrooms and their quality. Opting for a low-quality mushroom supplement poses a risk to experiencing the full range of potential benefits, making your health a priority.

A key indicator of a high-quality functional mushroom product is its extraction from the mushroom and using the appropriate method. Three commonly used extraction methods for functional mushrooms are hot water, alcohol, and dual extraction (involving both hot water and alcohol).

The choice of the extraction method can impact the quality, and research indicates that not all methods are equally effective for every mushroom. Some methods may even remove medicinal constituents during the process. Therefore, it is crucial for supplement producers to understand which extraction method ensures maximum benefit and efficacy for their product.

• Hot water extraction involves heating the mushroom in water to draw out water-soluble compounds like polysaccharides and beta-glucans. The resulting liquid can be consumed directly or dried to create a powder concentrated with the beneficial compounds. 
• Alcohol extraction follows a comparable procedure but utilises alcohol instead of water to eliminate non-water-soluble compounds such as triterpenes.

Determining the optimal extraction method, whether hot water or alcohol, depends on the mushroom in question. Antioxi employs a hot water extraction approach for Poria Cocos.

Through the extraction processes, the liquids obtained are then evaporated, resulting in a single extract powder. This method ensures the highest potency and health benefits in the final product.

To guarantee the top-notch quality of your Poria Cocos mushroom supplement, check whether the product has utilised a hot water extraction method.

Click the link below to learn more about what to look for when choosing a high-quality mushroom supplement. 

Learn More

Dose, Safety, Side Effects

Dose

Baseline Dose

Start with 2 capsules or 1 gram per day for general wellness. This helps you experience the foundational benefits of Poria Cocos.

Enhanced Dose

For more pronounced effects, please get in touch with us. Our team can help you determine the best approach for your needs.

Flexible Dosage Regimen

Whether you prefer splitting the dose throughout the day or taking it all at once, the choice is yours. For optimal absorption, it is recommended to consume mushrooms on an empty stomach. However, if you have a sensitive constitution, consider splitting the dose and taking it after a meal.

Feeling unsure about where to begin? Schedule your free private online consultation with Marko, our Founder, and discover the perfect products to meet your wellness goals. Click here to book a free consultation with Marko.

Safety

Individuals with diabetes are advised to seek guidance from their healthcare provider before incorporating Poria Cocos into their diet, as it may impact blood sugar levels.

While some studies suggest that Poria Cocos may have anti-inflammatory effects, it can also stimulate the immune system. Therefore, individuals with autoimmune diseases should seek medical guidance before considering the use of Poria Cocos.
Do not consume Poria Cocos mushrooms within two weeks of undergoing surgery or if you suffer from a bleeding disorder.

For individuals who are pregnant, breastfeeding, or have an autoimmune disease, it is crucial to consult with a healthcare professional before considering the use of Poria Cocos mushrooms.

Do not consume Poria Cocos if you are allergic to mushrooms.

MEDICATION INTERACTIONS

At present, there is limited scientific evidence indicating that Poria cocos significantly interacts with prescription medications. Most available sources, including clinical databases such as Drugs.com, report no well-documented or confirmed drug interactions. However, some caution is warranted.

For example, Poria cocos glucan has demonstrated inhibition of platelet aggregation in laboratory settings. While the clinical relevance of this effect remains unclear, individuals taking blood-thinning medications should consult a healthcare professional before use.

Additionally, a 2023 study investigating a Poria cocos and Morus alba extract mixture found no significant inhibitory effects on major liver enzymes involved in drug metabolism—specifically cytochrome P450 (CYP) and UGT enzymes [41]. These enzymes are responsible for breaking down many medications, suggesting a low likelihood of metabolic herb–drug interactions. Still, more targeted studies are needed to confirm safety across a broader range of drug classes.

Until more comprehensive interaction studies are conducted, it is recommended that individuals who are:

• Taking medications for diabetes management,
• Taking blood-thinning medications,
• Taking immunosuppressive drugs,
• Taking chronic medications of any kind,
• Managing conditions like diabetes, hypertension, or clotting disorders, or
• Pregnant or breastfeeding

consult their healthcare provider before using Poria cocos supplements or extracts.

Your health and safety are important to us and we want to ensure all our customers use our products to their benefit, not detriment.

Side Effects

Poria Cocos has a long-standing reputation in traditional Chinese medicine as a “superior herb” and is historically described as “sweet, smooth, and devoid of toxicity.” Modern research strongly supports this view, showing that it is generally safe for both internal and external use when taken at recommended doses.

Toxicological studies in animals have confirmed that key compounds from Poria Cocos—including its polysaccharides—show no signs of acute toxicity, even at high doses. Organ function markers such as liver and kidney enzymes remained within normal range, and no harmful tissue changes were observed. These findings support the idea that Poria Cocos does not cause significant harm to vital organs, even during repeated or high-dose exposure [39].

In clinical contexts, Poria Cocos is usually used in doses of 10–15 grams per day and has not shown evidence of mutagenicity or genetic toxicity. While rare allergic reactions have been reported in isolated cases, they are believed to stem from individual sensitivities rather than a general safety concern [40].

In summary, based on current research, Poria Cocos is considered a safe and well-tolerated supplement for most people, with no significant toxicity observed at standard therapeutic doses.

How To Take Poria Cocos Mushrooms For Health Support

Powders vs. Capsules

For those with a fast-paced lifestyle, intricate recipes might not be in the cards. That's precisely why Antioxi has crafted an Organic Poria Cocos Extract available in convenient capsule form.

If you're a cooking enthusiast or favour the convenience of a powder, our Organic Poria Cocos extract in powder form could be an ideal option for you. Our Poria Cocos can be seamlessly incorporated into smoothies, stews, coffee and all your other favourite meals and drinks.

It's essential to note that there is no difference in potency between our powdered extracts and capsules. Our capsules contain the exact same powdered extract, guaranteeing uniform effectiveness throughout our product line.

Frequently Asked Questions

Are The Mushrooms Organic?

Our Poria Cocos is organically sourced and certified.

Is It Safe To Consume Medicinal Mushrooms During Pregnancy Or Whilst Breastfeeding?

While medicinal mushrooms can offer some great benefits during pregnancy such as strengthening immune health, improving digestion and of course the much needed energy boost, there is unfortunately not yet enough information regarding studies during pregnancy and whilst breastfeeding where we can confidently give advice.

The best would be to consult with your healthcare provider and/or midwife.

Can Children Use Medicinal Mushrooms?

Research regarding the use of medicinal mushrooms by children is still at its infancy. There is however an interesting study conducted in 2018 which investigated the effects of Reishi on immune system cells of 3-5 year olds. [42]

The study showed that Reishi increased immune system cell counts in the peripheral blood, which are crucial for defending against infections. The treatments were also well-tolerated and safe, with no abnormal increases in serum creatinine or hepatic aminotransferases. While the study shows promise in the safety and effectiveness of the use of medicinal mushrooms in children, we do always suggest consulting with your child's doctor prior to introducing anything new into their diet.

If you do get the go ahead we suggest reducing the diet to 1/4 of a dose for young children.

These findings suggest the need for more extended controlled clinical trials to evaluate the effectiveness of medicinal mushrooms in preventing infections in children.

What Is The Difference Between The Powder And Capsules?

There is no difference in terms of benefits. The only difference is preference of use.

What Is The Difference Between Using The 8 Mushroom Blend And Using An Individual Mushroom?

Our 8-blend mushroom product is like an all-in-one health elixir. It's perfect for those seeking overall well-being, boosting digestion, or just looking for a daily health lift.

However, if you're using mushrooms as targeted support for a specific health concern, say, Lion's Mane for cognitive clarity or Reishi for stress relief, the individual route is your best bet.

Are There Any Allergy Precautions/Medication Interactions?

Individuals with diabetes are advised to seek guidance from their healthcare provider before incorporating Poria Cocos into their diet, as it may impact blood sugar levels.

While some studies suggest that Poria Cocos may have anti-inflammatory effects, it can also stimulate the immune system. Therefore, individuals with autoimmune diseases should seek medical guidance before considering the use of Poria Cocos.

Do not consume Poria Cocos mushrooms within two weeks of undergoing surgery or if you suffer from a bleeding disorder.

For individuals who are pregnant, breastfeeding, or have an autoimmune disease, it is crucial to consult with a healthcare professional before considering the use of Poria Cocos mushrooms.

Do not consume Poria Cocos if you are allergic to mushrooms.

At present, there is limited scientific evidence indicating that Poria cocos significantly interacts with prescription medications. Most available sources, including clinical databases such as Drugs.com, report no well-documented or confirmed drug interactions. However, some caution is warranted.

For example, Poria cocos glucan has demonstrated inhibition of platelet aggregation in laboratory settings. While the clinical relevance of this effect remains unclear, individuals taking blood-thinning medications should consult a healthcare professional before use.

Additionally, a 2023 study investigating a Poria cocos and Morus alba extract mixture found no significant inhibitory effects on major liver enzymes involved in drug metabolism—specifically cytochrome P450 (CYP) and UGT enzymes [41]. These enzymes are responsible for breaking down many medications, suggesting a low likelihood of metabolic herb–drug interactions. Still, more targeted studies are needed to confirm safety across a broader range of drug classes.

Until more comprehensive interaction studies are conducted, it is recommended that individuals who are:

• Taking medications for diabetes management, 
• Taking blood-thinning medications,
• Taking immunosuppressive drugs,
• Taking chronic medications of any kind,
• Managing conditions like diabetes, hypertension, or clotting disorders, or
• Pregnant or breastfeeding

consult their healthcare provider before using Poria cocos supplements or extracts.

Please bear in mind that the information we provide is for educational purposes and shouldn't be considered a replacement for professional medical advice. 

Which Mushroom Extraction Do You Use?

The optimal extraction method once again depends on the mushroom itself. Different methods are used to promote and dissolve the unique active ingredients in the mushroom extracts and hence create a high spectrum mushroom extract.

The 3 different extraction methods:

1. Alcohol (ethanol)

This extraction is used to draw out the fat-soluble compounds in the mushrooms, such as the adaptogenic terpenoids.

2. Hot water

This extraction is used to extract the water-soluble compounds, the polysaccharides, and the immunomodulating Beta-D-glucans. The dual extraction process ensures you’re getting the full spectrum of compounds when it comes to a potent mushroom extract.

3. Dual extraction

Dual extraction refers to a combination of water and alcohol extraction. The dual extraction process ensures you’re getting the full spectrum of compounds when it comes to a mushroom where the active ingredients benefit from both alcohol and well as a water extract.

Hot water extraction works best for:

Cordyceps, Turkey Tail, Maitake, Tremella, Shiitake, Enokitake, Agaricus Blazei, Poria Cocos

Double (alcohol & water) extraction works best for:

Lion's Mane, Reishi, Chaga

Do You Use The Fruiting Body Or Mycelium?

We use the sclerotium of Poria Cocos.

We have a helpful article here which explains the different mushroom parts.

Resources

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